Perhaps its true that, as Thomas Wolfe wrote: "You can't go home again." Mostly because, as in Wolfe's case, after you write about the place you're from, people are waiting at the city gates with pitchforks and burning torches the next time you try to visit.
But another reason you can't go home again is that the shape you made upon leaving does not match your shape upon return...
Debra Marquart in The Horizontal World: Growing Up In the Middle of Nowhere: A Memoir